HDAC6 modulates myofibril stiffness and diastolic function of the heart
Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres.Titin stiffening is associated pear with the development of diastolic dysfunction (DD), while augmented titin compliance appears to impair systolic performance in dilated cardiomyopathy.We found that myofib